Introduction to Azotemia

Azotemia or nephrotoxicity or renal failure refers to the accumulation of nitrogenous substances (urea nitrogen and creatinine) in the blood, resulting from failure of the kidneys to remove them.
Kidneys are either of a pair of glandular organs in the upper abdominal cavity of human beings. They serve to separate water and waste products of metabolism from the blood and excrete them as urine, through the urinary bladder.
Glomeruli are the tiny clusters of capillaries in the kidneys which act as filters, initiating the formation of urine.

Pregnancy and Azotemia

Pregnancy or the condition or quality of being pregnant refers to the development of the young in the uterus.
Although in pregnancy, acute renal failure is not that frequent yet an early diagnosis and correct assessment may improve the subsequent expectations.

Corticosteroids and Azotemia

As all of us are well aware that our kidneys are incriminated in the percolation process as well as elimination of the byproducts ( secondary or incidental products )from the body; so some level of overexertion and pressure is incurred on them, by administration of steroids, on account of the fact that the latter are excreted in urine.

Nephrotic Syndrome and Azotemia

Nephrotic syndrome is a disease of the kidneys, which comprises a triad of:
 Proteinuria
 Hypoalbuminemia (As a result of injury to the percolating system of the kidneys, the albumin seeps out of the capillaries all over the body and settles into the surrounding tissue, causing edema. The level of albumin in the blood drops)
 Edema.

Amphotericin B and Azotemia

Amphotericin B is an antifungal drug, used for the treatment of fungal infections. Its antifungal effect is on account of disruption of fungal cell wall synthesis, due to its ability to bind to sterols.
Oral preparations of Amphotericin B are used to treat thrush (an infection of the mouth as well as vagina, caused by the yeast referred to as Candida fungus); Nappy rash in babes is also caused by the same fungus.

Gentamicin as a Cause of Azotemia

Gentamicin as a cause of Azotemia;

Kidney stones and Azotemia

Kidney stones, also known as renal calculi or nephrolithiasis, are of four types:
o Calcium stones:
o These are the most typical stones. The calcium which is not consumed by the bones and the muscles merges with oxalate and phosphate to form calcium oxalate stones and calcium phosphate stones respectively.
o Struvite stones: Such stones form as a result of urine infections. Such stones comprise magnesium and ammonia
o Uric acid stones: These stones are a result of too much acid in the urine
o Cystine stones: Such stones are infrequent.

Enlarged Prostate and Azotemia

Prostate is a reproductive muscular gland, which surrounds the urethra at the base of the urinary bladder; this gland is positioned in the pelvis of male gender only. It secretes an alkaline fluid, which is discharged with the sperms. This gland has to do with the making of semen.

High Protein Diet and Azotemia

Proteins are a large class of nitrogenous substances consisting of a complex of amino acids and containing carbon, hydrogen, nitrogen, oxygen, frequently sulfur and sometimes phosphorus, iron, iodine or other elements.
Proteins are macronutrients (any of the chemical elements) the building blocks of which are the amino acids. The latter are a large group of organic acids, that contain a carboxyl group and an amino group; they are necessary for all life and are water-soluble and crystalline. The amino acids are of two types:

Azotemia in Reference to Hepatic Encephalopathy

It is to be noted, that in a healthy individual, the portal vein, conveys the nitrogen containing compounds from the intestine, to the liver where eighty to ninety percent of it is metabolized through the urea cycle and is excreted instantaneously. The function of liver is to store glycogen (a polysaccharide) decompose RBCs, manufacture plasma proteins, produce hormones and play a significant role in detoxification (removal of poisonous substances from the body) side by side with the kidneys.. However in case of hepatic encephalopathy, this process is impaired.

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